Thesis Abstract

Abstract
The field of cancer therapy is continuously evolving with the aim of developing more effective and targeted treatment strategies. One promising approach is the development of novel drug delivery systems that can specifically target cancer cells while minimizing systemic toxicity. This thesis focuses on the design, development, and evaluation of such targeted drug delivery systems for cancer therapy. Chapter one provides an introduction to the study, presenting the background of the research, problem statement, objectives, limitations, scope, significance, and defining key terms. Chapter two presents a comprehensive literature review covering ten key aspects related to drug delivery systems, targeted cancer therapy, and current challenges in the field. Chapter three details the research methodology employed in this study, including the selection of materials, formulation of drug delivery systems, in vitro and in vivo evaluation methods, and data analysis techniques. The chapter includes eight sub-sections outlining the experimental procedures and techniques used to assess the efficacy and safety of the developed drug delivery systems. Chapter four presents a detailed discussion of the findings obtained from the experimental evaluations. Results regarding the targeting efficiency, cytotoxicity, pharmacokinetics, and biodistribution of the drug delivery systems are analyzed and discussed in the context of their potential for clinical application in targeted cancer therapy. In conclusion, chapter five provides a summary of the key findings of the study and discusses their implications for the field of cancer therapy. The thesis concludes with recommendations for future research directions and the potential translation of the developed drug delivery systems into clinical practice. Overall, this thesis contributes to the advancement of targeted cancer therapy by proposing novel drug delivery systems that exhibit enhanced targeting capabilities and reduced off-target effects. The findings of this study have the potential to improve the efficacy and safety of cancer treatment, ultimately benefiting patients and advancing the field of oncology.

Thesis Overview

The project "Development of novel drug delivery systems for targeted cancer therapy" aims to address the pressing need for more effective and precise treatments for cancer. Cancer remains a major health concern worldwide, with existing treatment options often causing significant side effects and limited efficacy due to their non-specific nature. Targeted drug delivery systems offer a promising approach to improve cancer treatment by delivering therapeutic agents directly to cancer cells while minimizing damage to healthy tissues. The research will focus on developing innovative drug delivery systems that can specifically target cancer cells, enhancing treatment efficacy and reducing adverse effects. Various types of drug delivery systems will be explored, including nanoparticles, liposomes, and micelles, which can be designed to carry anticancer drugs and release them selectively within the tumor microenvironment. These systems can be engineered to exploit the unique characteristics of cancer cells, such as overexpressed receptors or enzymes, for targeted delivery. The project will involve an in-depth investigation of the design, synthesis, and characterization of novel drug delivery systems, evaluating their ability to efficiently deliver drugs to cancer cells in preclinical models. The research will also assess the safety, pharmacokinetics, and therapeutic efficacy of these systems compared to conventional drug formulations. Furthermore, the study will explore the potential of combining targeted drug delivery systems with other treatment modalities, such as immunotherapy or gene therapy, to enhance the overall anticancer effect. By integrating multiple therapeutic strategies, the project aims to develop comprehensive and personalized approaches for cancer treatment. Overall, the research on the development of novel drug delivery systems for targeted cancer therapy holds great promise in revolutionizing cancer treatment by improving drug efficacy, reducing side effects, and ultimately enhancing patient outcomes. The findings of this study have the potential to significantly impact the field of oncology and pave the way for the development of more effective and personalized cancer therapies.