Thesis Abstract

Abstract
This thesis presents a comprehensive investigation into the development of novel drug delivery systems aimed at enhancing targeted cancer therapy. With the growing complexity and heterogeneity of cancer, traditional cancer treatments such as chemotherapy often result in significant side effects due to non-specific targeting of healthy tissues. Targeted drug delivery systems have emerged as a promising approach to improve the efficacy and reduce the side effects of cancer therapy. Chapter 1 introduces the research by providing an overview of the background of the study, the problem statement, objectives, limitations, scope, significance of the study, and the structure of the thesis. The chapter also includes the definition of key terms relevant to the research. Chapter 2 comprises a comprehensive literature review that explores existing drug delivery systems for cancer therapy. The review covers various types of drug delivery systems, including nanoparticles, liposomes, micelles, and polymer-drug conjugates. It also discusses the challenges and opportunities associated with targeted drug delivery in cancer treatment. Chapter 3 details the research methodology employed in this study. This includes the selection of materials, synthesis methods, characterization techniques, and in vitro and in vivo evaluation of the developed drug delivery systems. The chapter also outlines the experimental setup and data analysis procedures. Chapter 4 presents a detailed discussion of the findings obtained from the experimental studies. This includes the physicochemical characterization of the drug delivery systems, their drug release profiles, cellular uptake studies, cytotoxicity assessments, and in vivo efficacy evaluations. The chapter critically analyzes the results and discusses their implications in the context of targeted cancer therapy. Chapter 5 provides a conclusion and summary of the thesis. The key findings, implications, limitations, and future research directions are discussed in this chapter. The study underscores the importance of developing innovative drug delivery systems for targeted cancer therapy and highlights the potential impact of such systems on improving patient outcomes. In conclusion, this thesis contributes to the advancement of targeted cancer therapy by developing novel drug delivery systems that offer improved efficacy and reduced side effects. The research findings provide valuable insights into the design, development, and evaluation of targeted drug delivery systems for cancer treatment, paving the way for future advancements in the field. Keywords Drug delivery systems, targeted therapy, cancer, nanoparticles, liposomes, micelles, polymer-drug conjugates, efficacy, side effects.

Thesis Overview

The project titled "Development of novel drug delivery systems for targeted cancer therapy" aims to address the pressing need for more effective and precise treatment options for cancer patients. Cancer remains one of the leading causes of mortality worldwide, necessitating continuous advancements in therapeutic strategies. Conventional cancer treatments, such as chemotherapy and radiation therapy, often lack specificity and can cause significant side effects due to their non-selective nature. Therefore, the development of innovative drug delivery systems that can target cancer cells while sparing healthy tissues is crucial for improving treatment outcomes and patient quality of life. This research project will focus on designing and evaluating novel drug delivery systems that have the potential to enhance the efficacy and safety of cancer therapy. By harnessing the principles of nanotechnology, the project aims to develop targeted delivery platforms capable of delivering therapeutic agents specifically to cancer cells. These delivery systems may include nanoparticles, liposomes, micelles, or other nanocarriers that can encapsulate and deliver anti-cancer drugs with precision. The project will involve a comprehensive literature review to explore the current state-of-the-art in drug delivery systems for cancer therapy. This review will highlight the challenges and limitations of existing approaches and identify gaps in the field that warrant further research. Building on this knowledge, the research will proceed to design and optimize novel drug delivery systems tailored for specific types of cancer or patient populations. The methodology will comprise a series of experiments to investigate the physicochemical properties, drug loading capacity, release kinetics, and targeting efficiency of the developed delivery systems. In vitro and in vivo studies will be conducted to assess the cytotoxicity, cellular uptake, biodistribution, and therapeutic efficacy of the drug-loaded nanocarriers in preclinical cancer models. The research will also explore the potential synergistic effects of combining different therapeutic modalities within the drug delivery systems to enhance anti-cancer activity. The findings of this research project are expected to contribute to the advancement of targeted cancer therapy by providing valuable insights into the design, optimization, and evaluation of novel drug delivery systems. The development of more efficient and selective drug delivery platforms has the potential to revolutionize cancer treatment paradigms and improve patient outcomes. Ultimately, the ultimate goal of this research is to translate scientific discoveries into clinically relevant applications that can benefit cancer patients worldwide.