Thesis Abstract

Abstract
The development and evaluation of novel drug delivery systems for targeted cancer therapy is a critical area of research aimed at improving the efficacy and safety of cancer treatment. This thesis explores the design, development, and evaluation of innovative drug delivery systems that can precisely target cancer cells while minimizing side effects on healthy tissues. The study begins with a comprehensive literature review to provide a solid foundation for understanding the current landscape of drug delivery systems in cancer therapy. Various drug delivery strategies, including nanoparticles, liposomes, and polymer-based systems, are critically evaluated based on their ability to enhance drug delivery specificity and efficacy. The research methodology chapter outlines the experimental approach used to design and synthesize novel drug delivery systems. Key aspects such as particle size, surface modification, and drug loading capacity are systematically investigated to optimize the performance of the delivery systems. In vitro and in vivo studies are conducted to assess the targeting efficiency, cellular uptake, and anti-cancer efficacy of the developed drug delivery systems. The results from these studies are rigorously analyzed and discussed in chapter four, highlighting the key findings and implications for targeted cancer therapy. The findings of this study demonstrate the potential of novel drug delivery systems to significantly enhance the effectiveness of cancer treatment while minimizing off-target effects. The discussion delves into the mechanisms of action underlying the improved therapeutic outcomes observed with the developed systems. Furthermore, the limitations and challenges encountered during the research process are critically examined, providing insights into areas for future investigation and improvement. In conclusion, this thesis contributes to the advancement of drug delivery technology in cancer therapy by presenting innovative strategies for targeted drug delivery. The significance of the study lies in its potential to revolutionize cancer treatment by improving drug delivery precision and reducing systemic toxicity. The comprehensive evaluation of the developed drug delivery systems underscores their promising therapeutic potential in the field of targeted cancer therapy. Overall, this research lays a solid foundation for further exploration and refinement of novel drug delivery systems for enhanced cancer treatment outcomes.

Thesis Overview

The project titled "Development and Evaluation of Novel Drug Delivery Systems for Targeted Cancer Therapy" aims to address the significant challenge of effectively treating cancer while minimizing adverse effects on healthy tissues. Cancer remains a leading cause of mortality worldwide, with traditional treatments such as chemotherapy and radiation therapy often causing severe side effects due to the lack of specificity in targeting cancer cells. Therefore, there is a critical need to develop innovative drug delivery systems that can precisely target cancer cells, thereby enhancing treatment efficacy and reducing systemic toxicity. This research project will focus on the design, development, and evaluation of novel drug delivery systems tailored for targeted cancer therapy. The project will involve exploring various strategies for enhancing the specificity of drug delivery to cancer cells, such as the use of nanotechnology, targeting ligands, and stimuli-responsive systems. By harnessing these advanced technologies, the project aims to improve the therapeutic index of anticancer drugs, enabling higher doses to be delivered to tumor sites while sparing healthy tissues. The research will also involve the evaluation of these novel drug delivery systems in preclinical models of cancer to assess their efficacy, safety, and pharmacokinetic profiles. By conducting comprehensive in vitro and in vivo studies, the project aims to provide valuable insights into the performance of these systems and their potential for clinical translation. Overall, this research project holds significant promise in advancing the field of cancer therapy by developing innovative drug delivery systems that can enhance treatment outcomes and improve patient quality of life. The findings from this study have the potential to pave the way for the development of more targeted and efficient cancer therapies, ultimately contributing to the ongoing efforts to combat this devastating disease.