Thesis Abstract

Abstract
Cancer remains a major health challenge globally, with conventional treatments often associated with limited efficacy and significant side effects. In recent years, targeted drug delivery systems have emerged as a promising approach to enhance the therapeutic outcomes of anticancer drugs while minimizing off-target effects. This thesis focuses on the development of novel drug delivery systems specifically tailored for targeted cancer therapy. The research aims to address the limitations of current cancer treatments by designing innovative delivery systems that can specifically target cancer cells, improve drug bioavailability, and reduce systemic toxicity. Chapter One provides an introduction to the research, highlighting the background of the study, problem statement, objectives, limitations, scope, significance, structure of the thesis, and definition of key terms. The literature review in Chapter Two critically analyzes existing studies on drug delivery systems for targeted cancer therapy, examining various approaches, technologies, and challenges in the field. Chapter Three outlines the research methodology, detailing the experimental design, materials, and methods employed in the development and evaluation of novel drug delivery systems. The chapter covers aspects such as formulation development, characterization techniques, in vitro and in vivo studies, and data analysis procedures. In Chapter Four, the findings of the research are comprehensively discussed, including the design rationale of the developed drug delivery systems, their physicochemical properties, drug release profiles, cellular uptake mechanisms, and anticancer efficacy. The chapter also explores the potential mechanisms of action underlying the enhanced therapeutic effects observed in preclinical studies. Finally, Chapter Five presents the conclusions drawn from the research findings and provides a summary of the key outcomes and contributions of the study. The implications of the developed drug delivery systems for targeted cancer therapy are discussed, along with recommendations for future research directions. Overall, this thesis contributes to the advancement of drug delivery systems for targeted cancer therapy, offering novel approaches to improve treatment outcomes and patient quality of life. The findings underscore the potential of innovative drug delivery technologies in revolutionizing cancer treatment paradigms and paving the way for more effective and personalized therapeutic interventions.

Thesis Overview

The project titled "Development of Novel Drug Delivery Systems for Targeted Cancer Therapy" aims to address the critical need for more effective and targeted treatment options for cancer patients. Cancer remains one of the leading causes of mortality worldwide, with current treatment modalities often causing significant side effects and limited efficacy. The development of novel drug delivery systems offers a promising approach to enhance the effectiveness of cancer therapy while minimizing adverse effects on healthy tissues. This research project will focus on the design and evaluation of innovative drug delivery systems that can specifically target cancer cells, delivering therapeutic agents with precision and efficiency. By harnessing advanced technologies and materials, such as nanoparticles, liposomes, and polymer-based carriers, the project aims to enhance the bioavailability and therapeutic efficacy of anti-cancer drugs. The research will involve a comprehensive literature review to explore the current landscape of drug delivery systems in cancer therapy, identifying gaps and opportunities for innovation. Subsequently, the project will involve the design and synthesis of novel drug carriers, incorporating specific targeting ligands to enhance the selectivity of drug delivery to cancer cells. Furthermore, the project will involve in vitro and in vivo studies to evaluate the performance of the developed drug delivery systems in terms of drug release kinetics, cellular uptake, cytotoxicity, and therapeutic efficacy. These studies will aim to provide valuable insights into the mechanisms of action and potential benefits of the novel drug delivery systems in cancer treatment. Overall, the research overview underscores the importance of developing advanced drug delivery systems for targeted cancer therapy to improve patient outcomes and quality of life. By combining cutting-edge science with a focus on clinical relevance, this project seeks to contribute to the advancement of cancer treatment strategies and ultimately make a positive impact on the lives of cancer patients.