Thesis Abstract

Abstract
The development of novel drug delivery systems for targeted cancer therapy is a critical area of research in the field of pharmacy. This thesis focuses on the design, development, and evaluation of innovative drug delivery systems that can effectively target cancer cells while minimizing off-target effects. The primary objective of this research is to enhance the therapeutic efficacy of anti-cancer drugs and reduce their systemic toxicity through targeted drug delivery. Chapter 1 provides an introduction to the research topic, presenting the background of the study, problem statement, objectives, limitations, scope, significance, structure of the thesis, and definition of key terms. Chapter 2 comprises a comprehensive literature review covering ten key aspects of drug delivery systems for cancer therapy. Chapter 3 details the research methodology, including the selection of materials, formulation techniques, characterization methods, and in vitro/in vivo evaluation strategies. The findings of this study, discussed in Chapter 4, reveal the successful development of novel drug delivery systems with improved targeting abilities and enhanced anti-cancer efficacy. The discussion encompasses the design principles, characterization results, and comparative analysis of the developed formulations. The conclusion, presented in Chapter 5, summarizes the key findings, implications of the research, contributions to the field, and recommendations for future studies. The research outcomes demonstrate the potential of novel drug delivery systems to revolutionize cancer therapy by improving drug targeting, reducing side effects, and enhancing patient outcomes. This thesis contributes valuable insights to the field of pharmaceutical sciences, paving the way for the translation of advanced drug delivery technologies into clinical applications for targeted cancer treatment.

Thesis Overview

The project titled "Development of Novel Drug Delivery Systems for Targeted Cancer Therapy" aims to address the challenges faced in delivering effective treatments for cancer by developing innovative drug delivery systems. Cancer remains a leading cause of mortality worldwide, and current treatment options often come with severe side effects and limited efficacy due to the inability to specifically target cancer cells. Therefore, the development of novel drug delivery systems that can target cancer cells while minimizing damage to healthy tissues is crucial in improving cancer treatment outcomes. The research will focus on exploring and developing various drug delivery systems, such as nanoparticles, liposomes, and micelles, that can enhance the targeted delivery of anti-cancer drugs to tumor sites. These systems offer advantages such as improved drug solubility, stability, prolonged circulation time, and the ability to target specific receptors on cancer cells. By encapsulating anti-cancer drugs within these delivery systems, it is possible to enhance their accumulation at the tumor site, improve their therapeutic efficacy, and reduce systemic toxicity. The project will also investigate the potential of incorporating targeting ligands, such as antibodies or peptides, onto the surface of drug delivery systems to further enhance their specificity for cancer cells. These targeting ligands can recognize and bind to specific receptors overexpressed on cancer cells, allowing for precise delivery of therapeutic agents to tumors while sparing healthy tissues. Furthermore, the research will explore the use of stimuli-responsive drug delivery systems that can release anti-cancer drugs in response to specific triggers present in the tumor microenvironment, such as pH, enzymes, or temperature. This approach can further enhance the selectivity and efficacy of drug delivery to cancer cells, providing a more personalized and effective treatment strategy. Overall, the development of novel drug delivery systems for targeted cancer therapy holds great promise in revolutionizing cancer treatment by improving drug efficacy, reducing side effects, and ultimately enhancing patient outcomes. Through this research, we aim to contribute to the advancement of cancer therapeutics and pave the way for more effective and personalized treatment options for cancer patients.