Thesis Abstract

**Abstract
** Cancer continues to be a major health challenge globally, necessitating the development of innovative therapeutic strategies. This thesis focuses on the development of novel drug delivery systems for targeted cancer therapy. The aim is to enhance the efficacy and specificity of cancer treatment while minimizing adverse effects on healthy tissues. The introduction lays the foundation for the research by highlighting the significance of targeted drug delivery in cancer therapy. The background of the study provides a comprehensive overview of current challenges in cancer treatment and the potential of novel drug delivery systems to address these challenges. The problem statement identifies gaps in existing therapies and underscores the need for targeted approaches. The objectives of the study are outlined to guide the research process towards developing effective drug delivery systems for cancer therapy. The literature review delves into ten key areas, exploring the latest advancements in drug delivery technologies, targeted therapy approaches, and the impact of nanomedicine on cancer treatment. Various studies on nanocarriers, liposomes, and polymer-based drug delivery systems are critically evaluated to provide a comprehensive understanding of the field. The research methodology section outlines the approach taken to develop and test novel drug delivery systems. Key components include the selection of suitable drug carriers, optimization of formulation parameters, in vitro and in vivo evaluation methods, and data analysis techniques. The methodology also addresses ethical considerations and safety protocols in conducting research involving drug delivery systems. The discussion of findings chapter presents a detailed analysis of the experimental results, highlighting the efficacy and specificity of the developed drug delivery systems in targeting cancer cells. The findings are compared with existing therapies, emphasizing the advantages of the novel systems in improving treatment outcomes and reducing side effects. Key observations and trends are identified, providing insights for future research directions. In conclusion, the thesis summarizes the key findings and contributions of the study towards advancing targeted cancer therapy through novel drug delivery systems. The significance of the research in improving patient outcomes and quality of life is emphasized. Recommendations for further research and translation of the developed systems into clinical practice are provided, underscoring the potential impact of targeted drug delivery in revolutionizing cancer treatment. Overall, this thesis contributes to the growing body of knowledge in the field of cancer therapy and drug delivery, offering innovative solutions for the challenges faced in cancer treatment. The development of novel drug delivery systems holds promise for personalized and effective cancer therapy, marking a significant step towards improving patient care and outcomes in the fight against cancer.

Thesis Overview

The project titled "Development of Novel Drug Delivery Systems for Targeted Cancer Therapy" aims to address the pressing need for more effective and precise treatment options for cancer patients. Cancer remains a leading cause of mortality globally, with traditional treatments such as chemotherapy often causing significant side effects due to their non-specific targeting of both cancerous and healthy cells. Therefore, the development of novel drug delivery systems that can specifically target cancer cells while minimizing damage to healthy tissues holds great promise in improving treatment outcomes and quality of life for cancer patients. This research project will focus on the design, development, and evaluation of innovative drug delivery systems tailored for targeted cancer therapy. By incorporating advanced drug delivery technologies such as nanoparticles, liposomes, micelles, and antibody-drug conjugates, the aim is to enhance the specificity and efficacy of anticancer drugs while reducing systemic toxicity. These novel drug delivery systems will be engineered to selectively deliver therapeutic agents to cancer cells through active targeting mechanisms, such as ligand-receptor interactions or antigen-antibody recognition. The research will involve a multidisciplinary approach, integrating principles of pharmaceutical sciences, nanotechnology, bioconjugation chemistry, and cancer biology. Experimental studies will be conducted to assess the physicochemical properties, drug release kinetics, cellular uptake, and cytotoxicity of the developed drug delivery systems using in vitro and potentially in vivo models of cancer. Furthermore, the project will explore the feasibility of scaling up the production of these innovative drug delivery systems for potential clinical translation. Overall, this research overview highlights the significance of developing novel drug delivery systems for targeted cancer therapy as a promising strategy to improve the efficacy and safety of cancer treatment. The outcomes of this project have the potential to advance the field of oncology by offering more precise and personalized therapeutic options for cancer patients, ultimately contributing to the advancement of precision medicine in cancer care.