Thesis Abstract

Abstract
The field of cancer therapy continues to evolve, with ongoing efforts to enhance treatment efficacy and reduce adverse effects. Nanotechnology has emerged as a promising approach for developing novel drug delivery systems that can target cancer cells specifically. This thesis focuses on the development of advanced nanotechnology-based drug delivery systems for targeted cancer therapy. The primary objective is to design and evaluate the effectiveness of these systems in delivering anticancer drugs to tumor sites while minimizing off-target effects. Chapter 1 provides an introduction to the research topic, including the background of the study, problem statement, objectives, limitations, scope, significance, structure of the thesis, and definition of key terms. The literature review in Chapter 2 explores current research on nanotechnology-based drug delivery systems for cancer therapy, covering topics such as nanoparticle design, targeting strategies, drug loading techniques, and in vitro/in vivo studies. Chapter 3 outlines the research methodology employed in this study. It includes sections on the design and synthesis of nanoparticles, drug encapsulation methods, characterization techniques, in vitro drug release studies, cellular uptake assays, and in vivo evaluation using animal models. The methodology aims to assess the efficacy and safety of the developed drug delivery systems in delivering anticancer drugs to tumor cells. Chapter 4 presents a detailed discussion of the findings obtained from the experimental studies. This includes the characterization of the developed nanoparticles, drug release profiles, cellular uptake efficiency, cytotoxicity assays, and in vivo tumor targeting studies. The results are analyzed to evaluate the performance of the drug delivery systems in terms of targeting specificity, drug release kinetics, and therapeutic efficacy. In Chapter 5, the conclusion and summary of the thesis are provided. The key findings, implications, limitations of the study, and future research directions are discussed. Overall, this research contributes to the advancement of targeted cancer therapy through the development of innovative nanotechnology-based drug delivery systems. The potential impact of these systems on improving treatment outcomes and patient quality of life is highlighted. In conclusion, the development of novel drug delivery systems for targeted cancer therapy using nanotechnology represents a significant advancement in the field of oncology. The integration of nanotechnology with drug delivery offers unique opportunities to enhance the effectiveness of cancer treatment while minimizing side effects. This thesis underscores the importance of continued research and innovation in this area to address the challenges of cancer therapy and improve patient outcomes.

Thesis Overview

The project titled "Development of novel drug delivery systems for targeted cancer therapy using nanotechnology" aims to address the pressing need for more effective and targeted treatment options for cancer patients. Cancer remains one of the leading causes of death worldwide, and conventional chemotherapy often leads to severe side effects due to the lack of specificity in targeting cancer cells. This research focuses on leveraging nanotechnology to develop innovative drug delivery systems that can specifically target cancer cells while minimizing damage to healthy tissues. Nanotechnology offers unique advantages in drug delivery, such as increased drug stability, prolonged circulation time, and enhanced cellular uptake, which can significantly improve the efficacy and safety of cancer therapies. The project will begin with a comprehensive literature review to explore the current landscape of drug delivery systems in cancer therapy and identify gaps in existing approaches. This will be followed by the design and development of novel nanocarriers capable of encapsulating and delivering anticancer drugs specifically to tumor sites. The nanocarriers will be engineered to possess targeting ligands that can recognize and bind to cancer-specific markers, enabling precise delivery of therapeutic agents. In the subsequent stages of the research, in vitro and in vivo studies will be conducted to evaluate the efficacy and safety of the developed drug delivery systems. Cell culture models and animal models will be utilized to assess the targeting efficiency, cytotoxicity, and therapeutic effects of the nanocarriers. Emphasis will be placed on understanding the mechanisms of cellular uptake, intracellular drug release, and tumor inhibition to optimize the design of the drug delivery systems. The findings from this research have the potential to revolutionize cancer therapy by offering more precise, efficient, and less toxic treatment options for patients. The development of targeted drug delivery systems using nanotechnology represents a cutting-edge approach that could significantly impact the field of oncology and improve clinical outcomes for cancer patients.