Thesis Abstract

Abstract
The development of novel drug delivery systems holds immense potential in revolutionizing cancer therapy by enhancing drug targeting, reducing off-target effects, and improving treatment outcomes. This thesis focuses on the design and evaluation of innovative drug delivery systems tailored for targeted cancer therapy. The research encompasses a comprehensive review of existing literature, the formulation of research objectives, the implementation of research methodology, the discussion of findings, and the conclusion. The study begins with an introduction providing background information on cancer therapy, the limitations of current treatment modalities, and the rationale for developing novel drug delivery systems. The problem statement highlights the challenges faced in conventional cancer treatment methods and emphasizes the need for targeted drug delivery systems to improve efficacy and reduce adverse effects. The objectives of the study include the design and characterization of novel drug delivery systems, the evaluation of their performance in delivering anticancer agents specifically to tumor sites, and the assessment of their therapeutic efficacy compared to conventional treatment approaches. Limitations of the study are acknowledged, such as the complexity of cancer biology and the variability of tumor microenvironments, which may influence the effectiveness of drug delivery systems. The scope of the study encompasses the formulation and optimization of drug delivery systems using various nanotechnology-based approaches, including liposomes, nanoparticles, micelles, and polymer conjugates. The significance of the study lies in its potential to enhance treatment outcomes for cancer patients by improving drug delivery to tumor tissues while minimizing systemic toxicity. The structure of the thesis is outlined, detailing the organization of chapters and the flow of content from literature review to research methodology, findings discussion, and conclusion. Definitions of key terms are provided to clarify terminology used throughout the thesis. The literature review chapter critically analyzes existing research on drug delivery systems for cancer therapy, focusing on recent advancements, challenges, and opportunities for innovation. Key aspects such as targeting strategies, drug release mechanisms, and formulation techniques are explored to provide a comprehensive understanding of the field. The research methodology chapter outlines the experimental design, materials, and methods employed in formulating and characterizing novel drug delivery systems. Techniques such as particle size analysis, drug loading efficiency determination, and in vitro drug release studies are described in detail. The discussion of findings chapter presents the results of experimental evaluations, including the characterization of drug delivery systems, their targeting efficiency, and their cytotoxic effects on cancer cells. Comparative analyses with conventional treatment approaches are conducted to assess the superiority of novel drug delivery systems. In conclusion, the study highlights the potential of novel drug delivery systems for targeted cancer therapy in improving treatment outcomes and reducing side effects. Future research directions are suggested to further optimize and validate the efficacy of these innovative drug delivery platforms in clinical settings. Keywords Drug delivery systems, Cancer therapy, Targeted drug delivery, Nanotechnology, Anticancer agents, Tumor targeting, Therapeutic efficacy, Nanoparticles, Liposomes, Polymer conjugates.

Thesis Overview

The project titled "Development of novel drug delivery systems for targeted cancer therapy" aims to address the pressing need for more effective and precise treatments for cancer. Cancer remains one of the leading causes of death worldwide, and current treatment options often come with significant side effects and limited efficacy. This project seeks to develop innovative drug delivery systems that can specifically target cancer cells while minimizing harm to healthy tissues. The research will focus on designing and testing novel drug delivery systems that leverage advanced technologies, such as nanoparticles, liposomes, and hydrogels, to enhance the delivery of anticancer drugs to tumor sites. By incorporating targeting ligands or stimuli-responsive components, these systems will be engineered to selectively release therapeutic agents within cancer cells or in response to specific cues within the tumor microenvironment. The project will involve a comprehensive literature review to assess the current landscape of drug delivery systems for cancer therapy, identify gaps in existing approaches, and explore potential strategies for enhancing targeted drug delivery. Subsequently, the research methodology will include the design and synthesis of novel drug delivery systems, characterization of their physicochemical properties, evaluation of their drug release kinetics, and assessment of their cytotoxicity and anticancer efficacy in relevant cell and animal models. The findings of this research are expected to advance the field of cancer therapy by providing insights into the development of more targeted and efficient drug delivery systems for combating cancer. By improving the specificity and efficacy of anticancer treatments, these novel drug delivery systems have the potential to revolutionize cancer care and improve patient outcomes. In conclusion, the project on the development of novel drug delivery systems for targeted cancer therapy represents a critical step towards addressing the challenges of current cancer treatments and offering new hope for patients facing this devastating disease. Through interdisciplinary collaboration and cutting-edge research, this project aims to contribute to the advancement of precision medicine and personalized cancer therapy, ultimately leading to improved survival rates and quality of life for cancer patients.