This work, Chemistry and Therapeutic Effects of Analgesics is an effort to bring together various works which has been done about drugs with analgesic properties, comparison of their effectiveness to pain management and the chemistry associated to pain. It also seeks to bring to the interest of a chemist, the import of application of a specialized knowledge such as chemistry to preparing selected analgesics, showing latent potency of chemical knowledge in solving the problem of various types of pain, with relatively less cost. The effectiveness of analgesics cannot be over-emphasized; hence this work to an extent reveals the broad world of analgesic and enclosed it with such truth as how it’s been chemistry all along even to the therapeutic nature of these analgesics.