Thesis Abstract

Inflammation is a complex biological response of vascular tissue to harmful stimuli such as pathogen, damage cells or irritants. The urgency generated by in increased rate of stroke, atheroselerosis attributed to prolong use of cyclooxygenase-1 and 2 inhibitors have acceralated anti-inflammatory drug research over the last decade while synthetic pharmaceutical agents continued to dominate research, attention increasingly has been directed to natural products. These are often more affordable and available and sometimes are perceived as more effective than conventional anti-inflammatory drugs.
Anti-inflammation was carried out using 11 rats. That was divided into three groups of four rats each. Group 1 and 2 served as the positive and negative control respectively. Groups 3 and 4 received 200mg/kg b.w and 600mg/kg b.w. of the extracts respectively. However, it was discovered that the stem bark of crateva Adansonii showed greater significance anti-inflammatory activity when compared with the standard.

Thesis Overview