Thesis Abstract

<p> Dandruff is a scalp disorder which is characterized by excessive shedding of skin cells from the scalp. It is a common problem faced by people of all age groups. As the epidermal layer continually replaces itself, cells are pushed outward where they eventually die and flake off. For most individuals, these flakes of skin are too small to be visible. However, certain conditions cause cell turnover to be unusually rapid, especially in the scalp. It is hypothesized that for people with dandruff, skin cells may mature and be shed in 2–7 days, as opposed to around a month in people without dandruff. The result is that dead skin cells are shed in large, oily clumps, which appear as white or grayish flakes on the scalp, skin and clothes (De Angelis <em>et al.,</em>&nbsp;2005). Yeast like lipophilic basidiomyceteous fungus <em>Malassezia furfur</em>&nbsp;[<em>Pytirosporum ovale</em>] is the causative organism for dandruff (Arora <em>et al.,</em>&nbsp;2011). &nbsp;<em>Malassezia</em>&nbsp;converts the sebum lipid into fatty acids and triglycerides, which accelerate hyperproliferation of keratinoytes (Singla <em>et al., </em>2011). The treatment options [ointments, lotions, shampoos] currently available for management of dandruff have zinc pyrithione, salicylic acid, imidazole derivatives, selenium sulphide, tar derivatives, ketocanazole etc. as key ingredients (Vijayakumar <em>et al.,</em>2006). These synthetic treatment options have certain limitations, which may be due to poor efficacies or due to compliance issues (Vijayakumar <em>et al., </em>2006). &nbsp;These are unable to prevent reoccurrence of dandruff with side effects that cannot be neglected. The best approach to treat dandruff is to use plants and herbal formulations which possess antidandruff properties. Studies evaluating antifungal effect of essential oils have also been reported (Lee <em>et al., </em>2010 Arora <em>et al., </em>2013). Antifungal activity of different plant extracts against <em>Malassezia furfur</em>&nbsp;is carried out in this work<strong>. </strong>Various natural plant extracts are known for their antidandruff properties. Evaluation of anti-fungal properties of such plant extracts can be done and they can be used effectively as an alternative to chemical agents in various anti dandruff formulations. Along with anti-fungal properties, plant extracts are also known for their conditioning properties which will be fruitful in maintaining the overall health of scalp and hair (Balakrishnan <em>et al</em>., 2011). <br></p>

Thesis Overview