Thesis Abstract

Abstract
The prevalence of obesity has become a global health concern, leading to an increased risk of various metabolic disorders. In recent years, research has highlighted the role of gut microbiota in influencing metabolic health, opening avenues for novel therapeutic strategies. Probiotics, live microorganisms with potential health benefits, have been studied for their impact on gut microbiota composition and metabolic parameters. This thesis investigates the effect of probiotics supplementation on gut microbiota composition and metabolic health in individuals with obesity. Chapter One provides an introduction to the study, presenting the background, problem statement, objectives, limitations, scope, significance, structure of the thesis, and definition of terms. Chapter Two comprises a comprehensive literature review focusing on ten key aspects related to probiotics, gut microbiota, obesity, and metabolic health. Chapter Three outlines the research methodology, detailing the study design, participant selection criteria, probiotics intervention protocol, data collection methods, and statistical analysis procedures. This chapter also discusses ethical considerations, potential biases, and limitations of the methodology. In Chapter Four, the findings of the study are extensively discussed, addressing the impact of probiotics supplementation on gut microbiota composition and various metabolic parameters such as body weight, blood glucose levels, lipid profile, and inflammatory markers. The results are analyzed in the context of existing literature and potential mechanisms underlying the observed effects are explored. Chapter Five presents the conclusion and summary of the thesis, highlighting the key findings, implications for clinical practice, and recommendations for future research. The study contributes to the growing body of evidence supporting the use of probiotics as a potential therapeutic approach for improving gut microbiota composition and metabolic health in individuals with obesity. In conclusion, this thesis sheds light on the potential benefits of probiotics supplementation in modulating gut microbiota composition and improving metabolic health outcomes in individuals with obesity. The findings underscore the importance of further research in this area to optimize probiotics interventions and enhance the management of obesity-related metabolic disorders.

Thesis Overview

The research project titled "Effect of Probiotics Supplementation on Gut Microbiota Composition and Metabolic Health in Individuals with Obesity" aims to investigate the impact of probiotics supplementation on the gut microbiota composition and metabolic health of individuals who are classified as obese. Obesity is a major public health concern globally, associated with various metabolic disorders such as insulin resistance, dyslipidemia, and inflammation, which can significantly increase the risk of chronic diseases like type 2 diabetes and cardiovascular diseases. The project will focus on probiotics, which are live microorganisms that when administered in adequate amounts, can confer health benefits to the host. Probiotics have been suggested to modulate the gut microbiota, which plays a crucial role in metabolism, immune function, and overall health. By studying the effects of probiotics supplementation on individuals with obesity, this research seeks to provide valuable insights into the potential therapeutic role of probiotics in managing obesity-related metabolic abnormalities. The study will involve recruiting a sample of individuals with obesity and randomly assigning them to receive either probiotics supplementation or a placebo for a specified duration. Various parameters related to gut microbiota composition, metabolic health markers such as blood glucose levels, lipid profiles, and inflammatory markers will be assessed before and after the intervention. Advanced techniques such as next-generation sequencing will be employed to analyze changes in the gut microbiota composition. The research overview will delve into the current understanding of the relationship between gut microbiota, obesity, and metabolic health, highlighting the gaps in existing knowledge that warrant further investigation. The project aims to contribute to the growing body of evidence on the potential benefits of probiotics in managing obesity and associated metabolic disorders. The findings from this study could have implications for the development of novel therapeutic strategies targeting the gut microbiota to improve metabolic health outcomes in individuals with obesity. Through a comprehensive analysis of the effects of probiotics supplementation on gut microbiota composition and metabolic health in individuals with obesity, this research project seeks to advance our understanding of the intricate interplay between the gut microbiota and metabolic health. The outcomes of this study have the potential to inform future interventions aimed at improving health outcomes in individuals with obesity and may pave the way for personalized approaches to managing metabolic disorders through targeted modulation of the gut microbiota.