Thesis Abstract

Abstract
This thesis investigates the effects of probiotics supplementation on gut microbiota composition in individuals diagnosed with Irritable Bowel Syndrome (IBS). The study aims to address the potential therapeutic benefits of probiotics in managing IBS symptoms by modulating the gut microbiota. A comprehensive review of the existing literature on probiotics, gut microbiota, and IBS provides the foundation for this research. The methodology involves a randomized controlled trial where participants with IBS will be administered a specific probiotic supplement for a defined period. Various molecular techniques, such as next-generation sequencing, will be employed to analyze the changes in gut microbiota composition pre- and post-probiotic supplementation. The findings from this study are expected to contribute to the understanding of how probiotics influence gut microbiota and potentially alleviate symptoms associated with IBS. Moreover, the implications of these findings on clinical practice and future research in the field of human nutrition and dietetics will be discussed. This thesis underscores the significance of personalized nutrition interventions, such as probiotics supplementation, in promoting gut health and overall well-being in individuals with IBS.

Thesis Overview

The project titled "Effects of Probiotics Supplementation on Gut Microbiota Composition in Individuals with Irritable Bowel Syndrome" aims to investigate the potential impact of probiotics supplementation on the gut microbiota composition in individuals diagnosed with Irritable Bowel Syndrome (IBS). Irritable Bowel Syndrome is a common gastrointestinal disorder characterized by symptoms such as abdominal pain, bloating, and changes in bowel habits. The condition has been associated with alterations in the gut microbiota, the complex community of microorganisms residing in the gastrointestinal tract that play a crucial role in maintaining gut health and overall well-being. Probiotics are live microorganisms that, when administered in adequate amounts, confer health benefits to the host. They are known to modulate the composition and function of the gut microbiota, potentially influencing the symptoms and severity of digestive disorders like IBS. This project seeks to explore how specific probiotic strains may interact with the gut microbiota of individuals with IBS and whether these interactions can lead to improvements in symptoms and overall gut health. The research will involve recruiting individuals diagnosed with IBS and dividing them into groups receiving different probiotic formulations or a placebo. The gut microbiota composition of the participants will be analyzed before and after the intervention using advanced sequencing techniques to assess changes in microbial diversity and abundance. In addition, clinical parameters such as symptom severity, bowel habits, and quality of life will be monitored to evaluate the effects of probiotics supplementation on IBS symptoms. By elucidating the effects of probiotics on the gut microbiota composition in individuals with IBS, this project aims to contribute valuable insights into the potential therapeutic role of probiotics in managing digestive disorders. The findings of this research could have implications for the development of personalized and effective dietary interventions for individuals with IBS, ultimately improving their quality of life and well-being.