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Estrogen receptor β and breast cancer

 

Table Of Contents


Chapter ONE

1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Research
1.9 Definition of Terms

Chapter TWO

2.1 Overview of Breast Cancer
2.2 Estrogen Receptor β in Breast Cancer
2.3 Role of Hormones in Breast Cancer Development
2.4 Genetic Factors in Breast Cancer
2.5 Current Treatment Options for Breast Cancer
2.6 Studies on Estrogen Receptor β and Breast Cancer
2.7 Impact of Estrogen Receptor β on Breast Cancer Prognosis
2.8 Emerging Therapies Targeting Estrogen Receptor β
2.9 Challenges in Targeting Estrogen Receptor β
2.10 Future Directions in Estrogen Receptor β Research

Chapter THREE

3.1 Research Design and Methodology
3.2 Selection of Study Participants
3.3 Data Collection Methods
3.4 Data Analysis Techniques
3.5 Ethical Considerations
3.6 Pilot Study Description
3.7 Sampling Techniques
3.8 Research Instruments Used

Chapter FOUR

4.1 Presentation of Research Findings
4.2 Analysis of Research Findings
4.3 Interpretation of Results
4.4 Comparison with Existing Literature
4.5 Discussion of Key Findings
4.6 Implications of Findings
4.7 Recommendations for Practice
4.8 Suggestions for Future Research

Chapter FIVE

5.1 Summary of Research
5.2 Conclusions Drawn from the Study
5.3 Contribution to Existing Knowledge
5.4 Practical Implications
5.5 Limitations of the Study
5.6 Recommendations for Further Research
5.7 Conclusion and Final Remarks

Thesis Abstract

Despite the primary role of estrogen receptor α (ERα) in mediating the effects of estrogen in malignant breast and as therapeutic target, the development of endocrine-resistant and metastatic phenotypes indicates the complexity of the mechanisms that regulate hormone signaling in the disease. The discovery of ERβ and its functional characterization has improved our understanding about the mechanism of estrogen receptor action, the regulation of estrogen signaling in breast tumors, and their response to therapy. The progressive decline of ERβ in pro-invasive lesions and invasive tumors points toward a role as suppressor of both tumorigenesis and progression in breast cancer. The antiproliferative and anti-invasive effects of the receptor and its agonists in preclinical models of breast cancer support these roles and delineate the mechanisms of action. The association of ERβ with clinical outcome proposes the potential use of the receptor as prognostic marker and its agonists in chemoprevention and therapeutic strategies for resistant and metastatic disease.

Thesis Overview

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